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Read this Patient Information leaflet before you start taking Pletal and each time you get a refillThere may be new informationThis information does not take the place of talking to your doctor about your medical condition or your treatment.

Compared to patients treated with placebopatients treated with Pletal 50 or 100 mg twice daily experienced statistically significant improvements in walking distances both for the distance before the onset of claudication pain and the distance before exercise-limiting symptoms supervenedmaximal walking distanceThe effect of Pletal on walking distance was seen as early as the first on-therapy observation point of two or four weeks.

Caution is needed when co-administering cilostazol with any other agent which has the potential to reduce blood pressure due to the possibility that there may be an additive hypotensive effect with a reflex tachycardiaRefer also to section 4.8.

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Pharmacokinetics are approximately dose proportionalCilostazol and its active metabolites have apparent elimination half-lives of about 11-13 hoursCilostazol and its active metabolites accumulate about 2-fold with chronic administration and reach steady state blood levels within a few daysThe pharmacokinetics of cilostazol and its two major active metabolites were similar in healthy subjects and patients with intermittent claudication due to peripheral arterial diseasePADFigure 1 shows the mean plasma concentration-time profile at steady state after multiple dosing of Pletal 100 mg twice daily.

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