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Pletal inhibits platelet aggregation in a reversible mannerPletalhas not been studied in patients with hemostatic disorders or active pathologic bleedingAvoid use of Pletal in these patients.

Older adults may be more sensitive to the side effects of this drugespecially swelling of the hands/feetfluid retentionor QT prolongationsee above

Administration of cilostazol with diltiazema weak inhibitor of CYP3A4resulted in an increase in the AUC of cilostazol of 44accompanied by a 4increase in AUC of the dehydro metabolite and a 43increase in the AUC of the 4trans-hydroxy metabolite.

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