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The hydrochlorothiazide contained in this medication could produce a positive analytic result in an anti-doping test.
Clinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone systemRAASthrough the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotensionhyperkalaemia and decreased renal functionincluding acute renal failurecompared to the use of a single RAAS-acting agentsee sections 4.34.4 and 5.1
You may also need to avoid taking Zestoretic with aliskiren if you have kidney disease.
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